CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

نویسندگان

  • Ke-Tai Guo
  • Angela Paul
  • Christian Schichor
  • Gerhard Ziemer
  • Hans P. Wendel
چکیده

Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.

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عنوان ژورنال:
  • International Journal of Molecular Sciences

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2008